Are advance reservations for museum tickets in italy worth the cost?

i'm going to italy in late sept and am wondering if it's worth the extra $$ to use a service to reserve tickets at museums (ie., the Uffizi in Florence, the Galleria Borghese in Rome). just how bad are the waiting lines at that time of year?
Actually, Borghese reservations are mandatory. They are easy to make online, and they don't charge you until you get there, so no loss if you decide not to go. This is their website

Also, in addition to Uffizi, I recommend you make reservation at the Academia to see David, if you are interested. You can always make reservations, and then go to the museum and if see there is no line, you don't have to use your reserved tickets, they don't charge you in advance. You can call Florence directly to make reservations for both museums together. To call from US and get an English operator, call 011- 39- 055-294-883 8:30-18:30 M-F and 8:30-12:00 Sat. Florence time.

Also, if you would like Vatican museum while in Rome, definitely make reservations there, the lines are huge.
Hope this helps.

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