How do Pilots find their path in air during their plight from one place to another?

I would like to know, how the air pilots find their path in the air to drive the aeroplane from one place to another during plight,that too at a higher altitude?
Just like driving on the road, pilots has routes in the sky too. They follow waypoints. That is their GPS system. Waypoints are like satellites that is on the ground and it tells the pilots how close to that waypoint. They follow the waypoints that are set by the FAA. There are thousands of them in the US and that's how the know where they're going from orgin to destination. I fly online on Flight Simulator 2004/VATSIM and we have to use the real world flight routes to fly online.

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